PUBLICATIONS
Recent Publications
SPOTting stress at the mitochondrial outer membrane
Schuler MH, Hughes AL.
Mol Cell. 2022 Mar 17;82(6)
Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
Schuler MH, English AM, Xiao T, Campbell TJ, Shaw JM, Hughes AL.
Mol Cell. 2021 Sep 16;81(18)
A nuclear-based quality control pathway for non-imported mitochondrial proteins
Shakya VP, Barbeau WA, Xiao T, Knutson CS, Schuler MH, Hughes AL.
Elife. 2021 Mar 18;10
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
Xiao T, Shakya VP, Hughes AL.
Life Sci Alliance. 2021 Jan 21;4(3)
ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis
English AM, Schuler MH, Xiao T, Kornmann B, Shaw JM, Hughes AL.
J Cell Biol. 2020 Dec 7;219(12)
OPA1 and Angiogenesis: Beyond the Fusion Function
Schuler MH, Hughes AL.
Cell Metab. 2020 May 5;31(5):886-887.
Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis
Casey E. Hughes, Troy K. Coody, Mi-Young Jeong, Jordan A. Berg, Dennis R. Winge, Adam L. Hughes
Cell 180, 296–310. January 23, 2020.
Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering
English AM, Hughes AL.
Dev Cell. 2019 Aug 5;50(3):259-260.
Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress
Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL.
Mol Biol Cell. 2019 Aug 1;30(17):2141-2154.
Advancing the aging biology toolkit
Coody TK, Hughes AL.
Elife. 2018 Nov 28;7:e42976.
Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M, and Zalckvar E. (2018).
Nature Commun 9, 1761.
The crucial impact of lysosomes in aging and longevity
Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C.
Ageing Res Rev. 2016 Dec;32:2-12.
Selective sorting and destruction of mitochondrial membrane proteins in aged yeast
Hughes AL*, Hughes CE, Henderson KA, Yazvenko N, and Gottschling DE*. (2016)
Elife 5 pii: e13943. *Co-corresponding authors
Power(2): the power of yeast genetics applied to the powerhouse of the cell
Rutter J, Hughes AL.
Trends Endocrinol Metab. 2015 Feb;26(2):59-68
Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast
Henderson KA, Hughes AL, and Gottschling DE. (2014)
Elife 3 pii: e03504.
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
Hughes AL and Gottschling DE. (2012)
Nature 492, 261-265.
Reviews
Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering
English AM, Hughes A.
Dev Cell. 2019 Aug 5;50(3):259-260.
Advancing the aging biology toolkit
Coody TK and Hughes AL. (2018)
Elife 7, pii: e42976.
The crucial impact of lysosomes in aging and longevity
Carmona-Gutierrez D, Hughes AL, Madeo F, and Ruckenstuhl C. (2016)
Aging Research Reviews 32, 2-12.
The power of yeast applied to the powerhouse of the cell
Rutter J and Hughes AL. (2015).
Trends in Endo and Metab 26, 59-68.
Adam’s Ph.D. Publications
Insig regulates HMG-CoA Reductase by controlling enzyme phosphorylation in fission yeast
Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, and Espenshade PJ. (2008)
Cell Metabolism 8, 522-531.
Hughes AL, Stewart EV, and Espenshade PJ. (2008)
J of Lipid Research 49, 2001-2012.
Regulation of sterol synthesis in eukaryotes
Espenshade PJ and Hughes AL. (2007)
Annu Rev Genetics 41, 401-427.
4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress
Hughes AL, Lee CS, Bien CM, and Espenshade PJ. (2007)
J Biol Chem 282, 24388-24396.
Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus
Lee H, Bien CM, Hughes AL, Espenshade PJ, Kwon-Chung KJ, and Chang YC. (2007)
Cryptococcus neoformans. Molecular Microbiology 65, 1018-1033.
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes
Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, and Espenshade PJ. (2007)
Cell Metabolism 5, 143-149.
Todd BL, Stewart EV, Burg JS, Hughes AL, and Espenshade PJ. (2006)
Mol Cell Biol 26, 2817-31.
SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast
Hughes AL, Todd BL, and Espenshade PJ. (2005)
Cell 120, 831-42.
S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion
Warren CD, Eckley DM, Lee MS, Hanna JS, Hughes A, Peyser B, Jie C, Irizarry R, and Spencer FA. (2004)
Mol Biol Cell 15, 1724-35.