Like a well-functioning factory, our cells are highly organized—they utilize organelles to spatially compartmentalize cellular pathways, proteins, nucleic acids, and metabolites.
But what happens when this order breaks down? The short answer—
Chaos. Aging. Disease.
Research in the Hughes lab is focused on understanding how changes in the spatial compartmentation of cellular proteins and metabolites drives aging and disease, and identifying mechanisms cells use to combat this problem.
