PUBLICATIONS
Recent Publications
Alterations in lipid saturation trigger remodeling of the outer mitochondrial membrane
Wong S, Bertram KR, Balasubramaniam SS, Raghuram N, Knight T, Maschek JA, Cox JE, Hughes AL.
Mol Biol Cell. 2025 Oct 1;36(10):ar129.
Mitochondrial-derived compartments are multilamellar domains that encase membrane cargo and cytosol
Wilson ZN, West M, English AM, Odorizzi G, Hughes AL.
J Cell Biol. 2024 Nov 4;223(11):e202307035.
Mitochondrial-derived compartments remove surplus proteins from the outer mitochondrial membrane
Wilson ZN, Balasubramaniam SS, Wong S, Schuler MH, Wopat MJ, Hughes AL.
J Cell Biol. 2024 Nov 4;223(11):e202307036.
Amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial function
Raghuram N, Hughes AL.
bioRxiv [Preprint]. 2024 Jul 12:2024.07.09.602707. doi: 10.1101/2024.07.09.602707.
The phospholipids cardiolipin and phosphatidylethanolamine differentially regulate MDC biogenesis
Xiao T, English AM, Wilson ZN, Maschek JA, Cox JE, Hughes AL.
J Cell Biol. 2024 May 6;223(5):e202302069.
Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function
Zhao S, Hughes AL, Espenshade PJ.
MicroPubl Biol. 2022 Aug 23;2022:10.17912/micropub.biology.000631.
SPOTting stress at the mitochondrial outer membrane
Schuler MH, Hughes AL.
Mol Cell. 2022 Mar 17;82(6)
Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
Schuler MH, English AM, Xiao T, Campbell TJ, Shaw JM, Hughes AL.
Mol Cell. 2021 Sep 16;81(18)
A nuclear-based quality control pathway for non-imported mitochondrial proteins
Shakya VP, Barbeau WA, Xiao T, Knutson CS, Schuler MH, Hughes AL.
Elife. 2021 Mar 18;10
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
Xiao T, Shakya VP, Hughes AL.
Life Sci Alliance. 2021 Jan 21;4(3)
ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis
English AM, Schuler MH, Xiao T, Kornmann B, Shaw JM, Hughes AL.
J Cell Biol. 2020 Dec 7;219(12)
OPA1 and Angiogenesis: Beyond the Fusion Function
Schuler MH, Hughes AL.
Cell Metab. 2020 May 5;31(5):886-887.
Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis
Casey E. Hughes, Troy K. Coody, Mi-Young Jeong, Jordan A. Berg, Dennis R. Winge, Adam L. Hughes
Cell 180, 296–310. January 23, 2020.
Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering
English AM, Hughes AL.
Dev Cell. 2019 Aug 5;50(3):259-260.
Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress
Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL.
Mol Biol Cell. 2019 Aug 1;30(17):2141-2154.
Advancing the aging biology toolkit
Coody TK, Hughes AL.
Elife. 2018 Nov 28;7:e42976.
Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M, and Zalckvar E. (2018).
Nature Commun 9, 1761.
The crucial impact of lysosomes in aging and longevity
Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C.
Ageing Res Rev. 2016 Dec;32:2-12.
Selective sorting and destruction of mitochondrial membrane proteins in aged yeast
Hughes AL*, Hughes CE, Henderson KA, Yazvenko N, and Gottschling DE*. (2016)
Elife 5 pii: e13943. *Co-corresponding authors
Power(2): the power of yeast genetics applied to the powerhouse of the cell
Rutter J, Hughes AL.
Trends Endocrinol Metab. 2015 Feb;26(2):59-68
Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast
Henderson KA, Hughes AL, and Gottschling DE. (2014)
Elife 3 pii: e03504.
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
Hughes AL and Gottschling DE. (2012)
Nature 492, 261-265.
Reviews
Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering
English AM, Hughes A.
Dev Cell. 2019 Aug 5;50(3):259-260.
Advancing the aging biology toolkit
Coody TK and Hughes AL. (2018)
Elife 7, pii: e42976.
The crucial impact of lysosomes in aging and longevity
Carmona-Gutierrez D, Hughes AL, Madeo F, and Ruckenstuhl C. (2016)
Aging Research Reviews 32, 2-12.
The power of yeast applied to the powerhouse of the cell
Rutter J and Hughes AL. (2015).
Trends in Endo and Metab 26, 59-68.
Adam’s Ph.D. Publications
Insig regulates HMG-CoA Reductase by controlling enzyme phosphorylation in fission yeast
Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, and Espenshade PJ. (2008)
Cell Metabolism 8, 522-531.
Hughes AL, Stewart EV, and Espenshade PJ. (2008)
J of Lipid Research 49, 2001-2012.
Regulation of sterol synthesis in eukaryotes
Espenshade PJ and Hughes AL. (2007)
Annu Rev Genetics 41, 401-427.
4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress
Hughes AL, Lee CS, Bien CM, and Espenshade PJ. (2007)
J Biol Chem 282, 24388-24396.
Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus
Lee H, Bien CM, Hughes AL, Espenshade PJ, Kwon-Chung KJ, and Chang YC. (2007)
Cryptococcus neoformans. Molecular Microbiology 65, 1018-1033.
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes
Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, and Espenshade PJ. (2007)
Cell Metabolism 5, 143-149.
Todd BL, Stewart EV, Burg JS, Hughes AL, and Espenshade PJ. (2006)
Mol Cell Biol 26, 2817-31.
SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast
Hughes AL, Todd BL, and Espenshade PJ. (2005)
Cell 120, 831-42.
S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion
Warren CD, Eckley DM, Lee MS, Hanna JS, Hughes A, Peyser B, Jie C, Irizarry R, and Spencer FA. (2004)
Mol Biol Cell 15, 1724-35.